Günesdogan, Ufuk, Prof. Dr.

Group Leader, Developmental Biology

Since 2024: Professor for Biochemistry, Health and Medical University Erfurt, Germany

Since 2017: Group Leader at the University of Göttingen, Germany

2015-2017: Leverhulme Early Career Fellow at the Gurdon Institute, University of Cambridge, UK

2010-2015: Postdoctoral Research Associate at the Gurdon Institute, University of Cambridge, UK

2006-2010: Predoctoral fellow at the Max Planck Institute for Biophysical Chemistry, Göttingen, Germany

Undergraduate studies in biology at the University of Braunschweig, Germany

Major Research Interests
Our research focuses on understanding the development of mammalian primordial germ cells (PGCs), the precursors of sperm or egg. Hence, PGCs represent the only cell type that transmits genetic and epigenetic information to the next generation. In mammals, the developing embryo forms the postimplantation epiblast, the founder cell population of all embryonic cell types. While most of these cells give rise to organs and tissues, a few are set aside to become PGCs. Shortly after, PGCs undergo reprogramming including extensive transcriptional changes accompanied by epigenetic alterations. Our work addresses the fundamental questions: How is the transcriptional programme controlled and what are the functional implications of epigenetic modifications in PGCs? To address these questions, we make use of in vivo and in vitro model systems of PGC differentiation, genome-wide techniques and the CRIPSR/Cas9 genome editing tool.

Homepage Department/Research Group
https://www.uni-goettingen.de/en/dr.+ufuk+günesdogan/570660.html

ORCID: 0000-0002-8658-8022