Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Engelke, Michael, Dr.*


  • 2003: Department Biochemistry of the Immune System, University of Bielefeld, Germany
  • 2003 – 2004: Postdoctoral scientist, Department Biochemistry of the Immune System, University of Bielefeld, Germany
  • 2004: Postdoctoral scientist, Department of Biochemistry and Molecular Immunology, University of Bielefeld, Germany
  • 2004 – 2005: Postdoctoral scientist, Institute of Cellular and Molecular Immunology, University Medical Center Goettingen, Germany
  • Since 2005: Group leader, Institute of Cellular and Molecular Immunology, University Medical Center Goettingen, Germany




Major Research Interests

Development, activation, and differentiation of B lymphocytes, which provide adaptive humoral immunity by the production of antigen-specific antibodies, are strictly controlled by signals that are transduced by the B cell antigen receptor (BCR). Aberrant signal transduction can cause immunodeficiency, autoimmunity, or B cell neoplasia. We study details of BCR signal regulation that ensure survival of B cells and correct B cell responses. This includes the organisation of multi protein complexes that undergo phase separation, and their translocation towards the BCR.
Moreover, we aim at identifying dysregulated BCR processes that cause survival of Burkitt Lymphoma B cells, and characterized how inositol phosphatases control energy metabolism, which is mandatory for such an aggressively proliferating neoplasia.


Homepage Department/Research Group
https://www.immunologie.uni-goettingen.de


Selected Recent Publications


  • Wilke AC, Doebele C, Zindel A, Lee KS, Rieke SA, Ceribelli M, Comoglio F, Phelan JD, Wang JQ, Pikman Y, Jahn D, Häupl B, Schneider C, Scheich S, Tosto FA, Bohnenberger H, Stauder P, Schnütgen F, Slabicki M, Coulibaly ZA, Wolf S, Bojarczuk K, Chapuy B, Brandts CH, Stroebel P, Lewis CA, Engelke M, Xu X, Kim H, Dang TH, Schmitz R, Hodson DJ, Stegmaier K, Urlaub H, Serve H, Schmitt CA, Kreuz F, Knittel G, Rabinowitz JD, Reinhardt HC, Vander Heiden MG, Thomas C, Staudt LM, Zenz T, Oellerich T (2022). SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma. Blood. Jan 27;139(4):538-553.
  • Leo E Wong Arshiya Bhatt, Philipp S Erdmann, Zhen Hou, Joachim Maier, Sona Pirkuliyeva, Michael Engelke, Stefan Becker, Jürgen Plitzko, Jürgen Wienands, Christian Griesinger (2020). Tripartite phase separation of two signal effectors with vesicles priming B cell responsiveness. Nat Commun. Feb 11(1): 848. doi: 10.1038/s41467-020-14544-1.
  • Corso J, Pan KT, Walter R, Doebele C, Mohr S, Bohnenberger H, Ströbel P, Lenz C, Slabicki M, Hüllein J, Comoglio F, Rieger MA, Zenz T, Wienands J, Engelke M, Serve H, Urlaub H, Oellerich T (2016). Elucidation of tonic and activated B-cell receptor signaling in Burkitt's lymphoma provides insights into regulation of cell survival. Proc Natl Acad Sci U S A. May 17;113(20):5688-93.
  • Engelke M, Pirkuliyeva S, Kühn J, Wong L, Boyken J, Herrmann N, Becker S, Griesinger C, Wienands J (2014). Macromolecular assembly of the adaptor SLP-65 at intracellular vesicles in resting B cells. Science Signal. Aug 19; 7(339): ra79.
  • Engelke M., Oellerich T., Dittmann K., Hsiao, H.H., Urlaub, H., Serve H., Griesinger, C., Wienands, J. (2013). Feed-forward activation of phospholipase C2 via C2 domain-mediated binding to SLP65. J Immunol. 2013 Dec 1;191(11):5354-8.
  • Castello A.*, Gaya M., Tucholski J., Oellerich T., Lu K.H., Tafuri A., Pawson T., Wienands J., Engelke M.*, Batista F.D.* (2013). Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells. Nat Immunol Sep: 14(9): 966-975. *corresponding authors